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정유진 박사과정 학생, 조병관 교수 Nature Communications 논문 게재(2016.06)


The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)


Yujin Jeong1,2,*, Ji-Nu Kim3,*, Min Woo Kim3, Giselda Bucca4,w, Suhyung Cho1,2, Yeo Joon Yoon5,
Byung-Gee Kim3, Jung-Hye Roe6, Sun Chang Kim1,2,7, Colin P. Smith4,w & Byung-Kwan Cho1,2,7


Individual Streptomyces species have the genetic potential to produce a diverse array of
natural products of commercial, medical and veterinary interest. However, these products are
often not detectable under laboratory culture conditions. To harness their full biosynthetic
potential, it is important to develop a detailed understanding of the regulatory networks
that orchestrate their metabolism. Here we integrate nucleotide resolution genome-scale
measurements of the transcriptome and translatome of Streptomyces coelicolor, the model
antibiotic-producing actinomycete. Our systematic study determines 3,570 transcription start
sites and identifies 230 small RNAs and a considerable proportion (B21%) of leaderless
mRNAs; this enables deduction of genome-wide promoter architecture. Ribosome profiling
reveals that the translation efficiency of secondary metabolic genes is negatively correlated
with transcription and that several key antibiotic regulatory genes are translationally induced
at transition growth phase. These findings might facilitate the design of new approaches to
antibiotic discovery and development.


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