KAIST 생명과학과동창회
  • News & Events
  • Recruiting

Recruiting

조회 수 491 댓글 0

Postdoctoral Position at the Columbia University

 

The Lab of Dr. Choi in the Department of Pathology and Cell Biology at the Columbia University Medical Center is currently seeking a talented postdoctoral research scientist with interest in molecular-cellular mechanisms related to insulin signaling, trafficking and genome integrity. The candidate will employ a variety of techniques ranging from CRISPR screening, conventional biochemistry, cell biology and mouse genetics to achieve their project goals. The postdoctoral scientist will also be given opportunities to collaborate with experts in cryo-EM to understand the molecular mechanism of receptor tyrosine kinase activation.

 

Her research goal is to delineate mechanisms underlying the mutual regulation between cell division and metabolism by combining mouse genetics, cell biology, biochemistry and cryo-EM structure. Perturbation of this regulation leads to cancer and metabolic diseases. Dr. Choi has discovered a critical role of cell division regulators in insulin signaling through regulating insulin receptor endocytosis. These findings link aneuploidy-suppressing genes to insulin signaling and suggest a mechanism by which a circulating hormone may regulate genomic stability. Her laboratory will study the role of cell division regulators in insulin signaling and will expand it to other receptor tyrosine kinases to discover how systemic signaling communicates with cell division process to maintain both genomic stability and metabolic homeostasis.

 

Recently, collaboration with Xiaochen Bai in UTSW, she discovered that large-scale conformational change of insulin receptor driven by insulin binding relieves its auto-inhibition, triggering trans-autophosphorylation of the kinase domain and hence initiation of downstream signaling cascade. How this conformational change induces kinase activation, how the activated kinase selectively provokes the signaling branch, and how the active insulin receptor can be preferentially internalized are not fully understood. Her laboratory will reveal how insulin activates the receptor kinase and insulin signaling, and initiates the receptor endocytosis at the molecular level, and how this process maintains systemic homeostasis in vivo. Along the way, they hope to unravel new molecular targets that will be useful to treat two very prevalent diseases, Diabetes and Cancer. 

 

For this position, general knowledge of molecular biology and cell biology is required. Experience in metabolic studies using mouse is ideal but not required.

 

Please send CV and the names of three academic references via email to: Eunhee Choi, PhD (EC3477@cumc.columbia.edu).


List of Articles
번호 제목 글쓴이 날짜 조회 수
112 [Postdoctoral fellow posiotion] UT Southwestern Medical Center file 생명과학과 2022.07.28 47
111 [Postdoctoral Fellow Positions] University Children’s Hospital Zürich file 생명과학과 2022.07.25 49
110 (주)씨앤큐어 2022년 상반기 연구원 채용 공고 file 생명과학과 2022.06.22 64
109 [한국NSK㈜] 2021년 영업관리직 신입사원 모집 (~4/21) 생명과학과 2021.04.19 71
108 [DL건설] 2021년 DL건설 신입사원 수시채용 생명과학과 2021.04.13 74
107 [포스코건설] 2021 상반기 채용연계형 인턴 신입 채용 (~5.3 13시) 생명과학과 2021.04.14 76
106 [동원그룹] 2021 상반기 채용연계형 인턴모집 (~5/10) 생명과학과 2021.04.20 85
105 [Post Doc] Dr, Jian Xu at Children's Research Institute, UT Southwestern Medical Center file 생명과학과 2022.05.23 87
104 미래과학기술지주(주) 신입/경력 채용 공고 file 생명과학과 2022.06.24 88
103 [2021년 LG상사 신입사원 수시채용] 생명과학과 2021.04.14 93
102 [한샘인테리어] 2021년 한샘인테리어 신입 IC 공개채용 생명과학과 2021.04.27 94
101 [EA코리아] SUMMER INTERN 온라인 채용상담 안내 생명과학과 2021.04.26 96
100 [카카오] 2021 카카오 인턴십 모집 (Service & Biz, Tech) 생명과학과 2021.04.16 99
99 [한화파워시스템] 2021년 상반기 경력사원 채용 생명과학과 2021.04.19 100
98 [NC문화재단] 프로젝토리 크루 모집 (~4.23) 생명과학과 2021.04.06 101
97 [(주)대림] 2021년 (주)대림 신입사원 모집 생명과학과 2021.04.07 106
96 2021 NCSOFT SUMMER INTERN(~5/6 14시) 생명과학과 2021.04.22 107
95 [ABInBev Korea 오비맥주] 2021년 상반기 GMT/SET Summer Intern 모집 (~4/20 기간 연장) 생명과학과 2021.04.05 107
94 한국투자증권] CEO LIVE 채용설명회 안내 (참가시 서류전형 우대) 생명과학과 2021.04.20 108
93 [포스코인터내셔널] '21상 채용전환형 인턴 채용 (~3.19) 생명과학과 2021.03.18 108
Board Pagination Prev 1 2 3 4 5 6 Next
/ 6