1.연사 및 연제
① 송지환 교수 (포천중문의대)
- Differentiation and in vivo application of embryonic stem cell.
② 이재운 교수 (Baylor College of Medicine)
- Hormone nuclear receptors and metabolic diseases.
2. 일시 : 2004년 6월 1일 (화) 오후 4:00
3. 장소 : 의과학센터 원격강의실
※ 문의 : 김태국 교수님 (2634)
※ ①'s Abstract
Stem cells provide the great hope for numerous areas, such as embryonic development, differentiation, nuclear cloning, cell transplantation, gene discovery, drug screening, and so on. Among various kinds of stem cells, embryonic stem (ES) cells are known to have the highest capacity, in terms of self-renewal and differentiation. With the isolation of human ES cell lines in recent years, the significance of stem cell research and its applications is continuously increasing. We are interested in various aspects of stem cell biology, especially using both mouse and human ES cells. In this presentation, I will outline the general features of ES cells and describe the methods of defining their pluripotent states, such as marker expression, telomerase activity and teratoma analysis. I will also describe their differentiation processes, both in spontaneous differentiation and directed differentiation. Among various cell types that can be differentiated from ES cells, we are interested in differentiating ES cells into neurons, in particular dopaminergic (DA) neurons, which will be useful to treat Parkinson's Disease (PD). PD is a progressive neurodegenerative disease, in which dopamine-producing neurons are selectively degenerated, giving rise to various symptoms of movement disorders. At present, L-dopa treatment and surgical procedures are being employed with some limited success, but these conventional approaches do not provide the fundamental solutions to cure PD permanently. Given the well-defined biology of nigrostriatal pathway, neural transplantation approach has been employed over the past years using various sources of cells, including human fetal brains. More recently, there has been the great interest in using stem cells, in particular ES cells as a source of neural transplantation to cure PD. In this presentation, I will also summarize the recent findings from the transplantation studies and discuss the future directions.
This work was supported by a grant from the Korean Ministry of Health and Welfare (01-PJ1-PG1-01CH11-0003).
① 송지환 교수 (포천중문의대)
- Differentiation and in vivo application of embryonic stem cell.
② 이재운 교수 (Baylor College of Medicine)
- Hormone nuclear receptors and metabolic diseases.
2. 일시 : 2004년 6월 1일 (화) 오후 4:00
3. 장소 : 의과학센터 원격강의실
※ 문의 : 김태국 교수님 (2634)
※ ①'s Abstract
Stem cells provide the great hope for numerous areas, such as embryonic development, differentiation, nuclear cloning, cell transplantation, gene discovery, drug screening, and so on. Among various kinds of stem cells, embryonic stem (ES) cells are known to have the highest capacity, in terms of self-renewal and differentiation. With the isolation of human ES cell lines in recent years, the significance of stem cell research and its applications is continuously increasing. We are interested in various aspects of stem cell biology, especially using both mouse and human ES cells. In this presentation, I will outline the general features of ES cells and describe the methods of defining their pluripotent states, such as marker expression, telomerase activity and teratoma analysis. I will also describe their differentiation processes, both in spontaneous differentiation and directed differentiation. Among various cell types that can be differentiated from ES cells, we are interested in differentiating ES cells into neurons, in particular dopaminergic (DA) neurons, which will be useful to treat Parkinson's Disease (PD). PD is a progressive neurodegenerative disease, in which dopamine-producing neurons are selectively degenerated, giving rise to various symptoms of movement disorders. At present, L-dopa treatment and surgical procedures are being employed with some limited success, but these conventional approaches do not provide the fundamental solutions to cure PD permanently. Given the well-defined biology of nigrostriatal pathway, neural transplantation approach has been employed over the past years using various sources of cells, including human fetal brains. More recently, there has been the great interest in using stem cells, in particular ES cells as a source of neural transplantation to cure PD. In this presentation, I will also summarize the recent findings from the transplantation studies and discuss the future directions.
This work was supported by a grant from the Korean Ministry of Health and Welfare (01-PJ1-PG1-01CH11-0003).
