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Recruiting

Postdoc Positions in Cancer Genomics, Epigenetics, Metabolism, and Bioinformatics

 

Multiple postdoctoral positions are available in the lab of Dr. Jian Xu at Children’s Research Institute (CRI), UT Southwestern Medical Center to study the gene regulatory processes that control stem cell development and cancers. We employ genomics, epigenetics, genome editing, metabolomics, and mouse genetics to define disease-associated epigenetic and genetic programs that control normal stem cell development, and how these processes go awry in cancer progression.

 

Our laboratory is equipped with cutting-edge genomics, molecular biology and bioinformatics platforms, and has access to many shared facilities including an in-house illumina sequencer, 10xGenomics singlecell technologies, metabolomics, transgenic mouse core, imaging, and flow cytometry. Our team brings together enthusiastic scientists with diverse backgrounds, and provides a wide range of perspectives in a multi-disciplinary and collaborative team setting. Since we established the laboratory in 2014, our team has published a series of impactful papers, which include:

 

 Development of a CRISPR-based CAPTURE approach for in situ analysis of chromatin interactions (Cell 170:1028, 2017)

 Post-transcriptional regulation of mitochondrial biogenesis and metabolism during erythropoiesis (Nature Cell Biology 19:626, 2017)

 Reported that loss of EZH2 reprograms branched-chain amino acid (BCAA) metabolism to drive leukemic transformation (Cancer Discovery 9:1228, 2019)

 Reported an integrative pipeline to identify pathogenic non-coding variants connecting enhancer dysregulation with nuclear receptor signaling in blood cancers (Cancer Discovery 10:724, 2020)

 Discovered that the epigenetic silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia (Nature Genetics 53:672, 2021) 

 

Some potential research projects:

 

 The crosstalk between epigenetic gene regulation and metabolism in development and cancer

 Engineering of CRISPR-based epigenomic editing and chromatin CAPTURE technologies for programmable gene regulation

 Enhancer function and mechanisms in stem cells and cancers

 The function and regulation of genomic transposable elements in development and cancer

 Single-cell lineage tracing of stem cell differentiation and cancer evolution

 

Candidates must hold a Ph.D. and/or M.D. degree with a strong background in molecular biology, cancer biology, mouse genetics, bioinformatics and/or a related field. The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity. Previous experience in epigenetics, genomics, metabolism, computational biology, mouse genetics, and/or hematologyoncology is strongly preferred.

 

Interested individuals should send a CV, a short summary of research interest and experience, and a list of three references to:

 

Jian Xu, Ph.D.

Associate Professor

Children’s Research Institute

CPRIT Scholar in Cancer Research

UT Southwestern Medical Center

Email: Jian.Xu@UTSouthwestern.edu 


List of Articles
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145 [NIH] KVSTA Fellowship 2023 공고 file 생명과학과 2023.05.04 190
144 [현대자동차] 2023 상반기 현대자동차 연구장학생/계약학과 모집(~23.5.14(일)) file 생명과학과 2023.05.02 193
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140 [KT] 2023년 KT 신입사원 채용( ~4/24) file 생명과학과 2023.04.18 150
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138 [삼양그룹] 2023년 4월 삼양그룹 신입사원 수시채용( ~ 4/27) file 생명과학과 2023.04.17 156
137 [NAVER] 2023 팀네이버 신입 공채 (~4.10 월 오전 11시) 생명과학과 2023.03.31 144
136 [Post-Doc] Epigenetic Inheritance and Cancer Epigenetics at Columbia University Irving Medical Center file 생명과학과 2023.03.13 206
135 [삼성에스원] 2023 상반기 3급 신입사원 채용 (~3/15 17시까지) 생명과학과 2023.03.09 181
134 [LIG넥스원] 2023 상반기 LIG넥스원 수시채용 생명과학과 2023.03.07 133
133 [커리어톡] 대기업 현직 및 인사팀과 함께하는 메타버스 잡페어 (~3/9, 이벤트 중) 생명과학과 2023.03.07 125
132 Open Research Positions - Laboratory of Cancer Ecology and Genomics (University of Michigan) file 생명과학과 2023.03.07 152
131 - [현대카드/현대커머셜] 2023 Internship - 생명과학과 2023.03.06 145
130 삼성바이오로직스 '23년 상반기 온라인 채용설명회 file 생명과학과 2023.03.06 290
129 [WorldQuant] 2023 IQC 대회 (International Quant Championship) 안내 생명과학과 2023.03.03 176
128 2023년 상반기 RIST 공개 채용 file 생명과학과 2023.03.03 150
127 [한화시스템] 2023 방산부문 신입사원 채용 (~3/1) 생명과학과 2023.02.20 155
126 [뷰웍스] 2023 뷰웍스 바이오영상 직무 채용공고 (2/13~2/28) file 생명과학과 2023.02.07 170
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