KAIST 생명과학과동창회
  • News & Events
  • Recruiting

Recruiting

조회 수 889 댓글 0

Postdoctoral Position at the Columbia University

 

The Lab of Dr. Choi in the Department of Pathology and Cell Biology at the Columbia University Medical Center is currently seeking a talented postdoctoral research scientist with interest in molecular-cellular mechanisms related to insulin signaling, trafficking and genome integrity. The candidate will employ a variety of techniques ranging from CRISPR screening, conventional biochemistry, cell biology and mouse genetics to achieve their project goals. The postdoctoral scientist will also be given opportunities to collaborate with experts in cryo-EM to understand the molecular mechanism of receptor tyrosine kinase activation.

 

Her research goal is to delineate mechanisms underlying the mutual regulation between cell division and metabolism by combining mouse genetics, cell biology, biochemistry and cryo-EM structure. Perturbation of this regulation leads to cancer and metabolic diseases. Dr. Choi has discovered a critical role of cell division regulators in insulin signaling through regulating insulin receptor endocytosis. These findings link aneuploidy-suppressing genes to insulin signaling and suggest a mechanism by which a circulating hormone may regulate genomic stability. Her laboratory will study the role of cell division regulators in insulin signaling and will expand it to other receptor tyrosine kinases to discover how systemic signaling communicates with cell division process to maintain both genomic stability and metabolic homeostasis.

 

Recently, collaboration with Xiaochen Bai in UTSW, she discovered that large-scale conformational change of insulin receptor driven by insulin binding relieves its auto-inhibition, triggering trans-autophosphorylation of the kinase domain and hence initiation of downstream signaling cascade. How this conformational change induces kinase activation, how the activated kinase selectively provokes the signaling branch, and how the active insulin receptor can be preferentially internalized are not fully understood. Her laboratory will reveal how insulin activates the receptor kinase and insulin signaling, and initiates the receptor endocytosis at the molecular level, and how this process maintains systemic homeostasis in vivo. Along the way, they hope to unravel new molecular targets that will be useful to treat two very prevalent diseases, Diabetes and Cancer. 

 

For this position, general knowledge of molecular biology and cell biology is required. Experience in metabolic studies using mouse is ideal but not required.

 

Please send CV and the names of three academic references via email to: Eunhee Choi, PhD (EC3477@cumc.columbia.edu).


List of Articles
번호 제목 글쓴이 날짜 조회 수
348 [하나은행] K-Digital Training 디지털하나로 모집 (~2/23(일)) 18:00 file 생명과학과 2025.02.10 3
347 [포스코스틸리온] 2025년 상반기 대졸 신입(채용연계형 인턴)/경력 채용(~2/17) file 생명과학과 2025.02.06 8
346 2025 상반기 삼성전자 MX사업부 박사 채용 안내 file 생명과학과 2025.02.06 18
345 2025 상반기 아모레퍼시픽 신입사원 수시채용(~2/10)*회사 추가 file 생명과학과 2025.02.06 14
344 [인테그리스코리아] 2025 글로벌 리더 (신입) 채용 (~2/23) file 생명과학과 2025.01.24 26
343 DGIST 까치연구팀) 2025년 대전 까치 현장 조사 인턴 모집 file 생명과학과 2025.01.23 50
342 [LG사이언스파크] LG사이언스파크 서포터즈 이공계091 2기 모집(~2/2) file 생명과학과 2025.01.20 55
341 2025 상반기 아모레퍼시픽 신입사원 수시채용(~2/10) file 생명과학과 2025.01.20 40
340 [Post-doc] 정형록 교수 연구실 박사후연구원 모집 공고 / Department of Neurology at Houston Methodist Research Institute/Weill Cornell Medicine. file 생명과학과 2025.01.15 55
339 [삼성글로벌리서치(옛 삼성경제연구소)] 채용공고 안내 (~1/31(금)까지) 생명과학과 2025.01.13 84
338 [폭스바겐그룹코리아] 2025 H1 INTERNSHIP PROGRAM(~1/5) file 생명과학과 2024.12.24 81
337 ★이번주마감★ [롯데케미칼 첨단소재사업] 2024년 12월 신입사원 채용 일반전형 file 생명과학과 2024.12.10 91
336 [LX판토스] 2025 상반기 채용연계형 인턴십 채용 (~12.22까지) file 생명과학과 2024.12.09 81
335 [BGF리테일 2025년 동계 채용연계형 인턴 모집] file 생명과학과 2024.12.09 92
334 [BGF로지스 2024년 4분기 신입 및 경력사원 공개채용] file 생명과학과 2024.12.09 54
333 [롯데그룹] 3·6·9·12 예측가능한 롯데그룹 12월 채용 오픈 (12/2~) file 생명과학과 2024.12.02 65
332 [베이글코드] 2024 베이글코드 공개채용 (~12/1) file 생명과학과 2024.11.19 92
331 2024년 우리은행 체험형 인턴 채용 (11/29 18시까지) file 생명과학과 2024.11.18 114
330 [LX인터내셔널] Business Academy 5기 참가자 모집 (~11/24) file 생명과학과 2024.11.18 66
329 [삼성메디슨] 2024 하반기 3급 신입사원 채용 (~11/18) file 생명과학과 2024.11.11 149
Board Pagination Prev 1 2 3 4 5 6 7 8 9 10 ... 18 Next
/ 18