KAIST 생명과학과동창회
  • News & Events
  • News

News

November 19, 2020

Newly discovered metabolic pathway uses single carbon gases as a feedstock

by




18-newlydiscove.jpg


Figure 1. Acetyl-CoA production ratio in wild-type and knockout strains. Credit:  


A joint research team, affiliated with UNIST has identified a new metabolic pathway, in which microorganisms use single carbon (C1) gasses (CO and CO2) as a feedstock. The new metabolic pathway is thought to be the most energetically efficient pathway, compared to the existing ones, and thus is expected to be used in a variety of industrial applications that involved the conversion of C1 gas into value-added biochemicals.


Published in Proceedings of the National Academy of Sciences, this research has been jointly carried out by Professor Donghyuk Kim (School of Energy and Chemical Engineering, UNIST) and Professor Byung-Kwan Cho (Department of Biological Sciences, KAIST), joined by Dr. Yoseb Song (Department of Biological Sciences, KAIST) as the first author.

There are currently six autotrophic CO2 fixation pathways, capable of converting C1 gas into and one representative example is the photosynthesis in plants. Among those CO2-fixing in nature, the linear wood-ljungdahl (WLP) in phylogenetically diverse acetateforming acetogens is known to be the most energetically efficient pathway to fix C1 compounds. In particular, acetogens play an important role in the , with nearly 1,013 kg (100 billion US tons) of acetic acid being formed annually.


However, the growth rate of acetogens is 10 times slower than that of industrial microorganisms, such as E. coli. And this puts a limit on its use as industrial microorganisms for the conversion of C1 gas into useful biochemical products. Accordingly, many studies on a new and more effective CO2 fixation have been carried out.


19-newlydiscove.jpg

Figure 2. Construction of the genome-scale metabolic network model of C. drakei


The research team paid special attention to the growth rate of Clostridium drakei, which was faster than that of the other microorganisms, when accompanied by CO2 absorption. And, through this, they expected they might find clues to enhance the C1 gas conversion efficiency.


In this study, using the reconstructed genome-scale metabolic model iSL771 based on the completed genome sequence, transcriptomics, 13C isotope-based metabolite-tracing experiments, biochemical assays, and heterologous expression of the pathway in another acetogen, the research team discovered that the WLP and the glycine synthase pathway are functionally interconnected to fix CO2, subsequently converting CO2 into acetyl-CoA, acetyl-phosphate, and serine.


Moreover, the functional cooperation of the pathways enhances CO2 consumption and cellular growth rates via bypassing reducing power required reactions for cellular metabolism during autotrophic growth of acetogens.

"With the new CO2-fixing metabolic pathway, we shall overcome limitations in the biosynthesis for the production of high value-added compounds, brought by the slow growth rate of acetogens," says Professor Kim. 



https://phys.org/news/2020-11-newly-metabolic-pathway-carbon-gases.html


List of Articles
번호 제목 글쓴이 날짜 조회 수
288 [동아일보] 한국 과학에 세계가 또 놀라다 -정종경교수팀 과사무실 2006.05.04 14286
287 [동아일보] 혈관형성 촉진제 이용 만성 신장질환 고쳐요-고규영교수 과사무실 2006.08.04 11313
286 [매일경제] 고규영 교수 "혈관생성물질 세계 첫 개발" 과사무실 2004.04.15 12395
285 [매일경제] 관절염 맞춤치료 길 열린다 - 강창원 교수·한양대 의대 배상철교수 공동연구팀 과사무실 2005.03.30 11569
284 [매일경제] 김은준 교수"퍼즐놀이하듯 신경세포 연구" 과사무실 2003.09.23 13952
283 [매일경제] 김학성 오은규 연구팀 나노입자 특성 이용해 단백질 상호작용 분석 과사무실 2005.03.22 10649
282 [서울경제] 생물분야: KAIST 생물사업단 선정 과사무실 2004.12.10 13702
281 [연합뉴스]신종 박테리아 5개중 1개꼴 한국과학자 발견...이성택교수 과사무실 2007.04.04 13271
280 [조선일보] AMPK유전자, 암세포 치료에도 이용...정종경 교수팀 과사무실 2007.05.08 11705
279 [조선일보] 김재섭 교수 고열에도 뇌손상 막는 유전자 최초 발견 과사무실 2005.01.31 11741
278 [조선일보] 생명과학과 김정회교수팀...자일리톨 추출 신기술 개발 과사무실 2007.08.29 13699
277 [중앙일보] 김재섭 교수 치매 막는 신물질 4종 발견 과사무실 2005.08.08 11756
276 [중앙일보] 생명과학과 박지혜 '로레알 여성생명과학상' 수상 과사무실 2006.06.22 13181
275 [한겨레] BK21 중간평가: 최우수사업단으로 선정 과사무실 2004.12.09 10358
274 [한겨레] 생체시계 시간 맞추는 유전자 국내 연구팀이 첫 발견-김재섭 교수팀 과사무실 2005.10.20 10677
273 [한국경제] STRONG KOREA-한국인 과학자가 뛴다...생명과학 과사무실 2006.11.13 16756
272 [한국경제] 고규영 교수 유력 바이오논문 6편 최다 발표 과사무실 2005.09.02 11626
271 [한국경제] 한국인 생명과학자가 최근 발표한 주요 연구 과사무실 2006.11.13 16160
270 [한국의 AI 추격자들] 서범석·백승욱 루닛 창업자 file 생명과학과 2020.10.30 1283
269 ‘올해의 KAIST 교수상’ - 김재섭 교수 과사무실 2005.12.30 12491
Board Pagination Prev 1 2 3 4 5 6 7 8 9 10 ... 17 Next
/ 17