KAIST 생명과학과동창회
  • News & Events
  • News

News

One More Key to Human Longevity Found After Worm Research

Korean scientists zero in on an enzyme called VRK-1 in roundworm research that can extend their lifespan


It is known that the mitochondria is called the powerhouse of the cell, without which there will be no energy production in the cell, thereby the body too! Along with this mitochondria has its role in other important functions, one crucial role being in aging.

Research has shown that age-related diseases are linked to mitochondrial functioning. Further, it is known that "mild inhibition of mitochondrial respiration" promotes longevity in many species, which means to mildly slow down mitochondria's energy-making process. Thus, the life-span extension compensates for the reduced mitochondrial respiration.

VRK-1 is a nuclear protein that increases worm life span
VRK-1 is a nuclear protein that increases worm life span From the Research Paper

An enzyme called AMP-activated protein kinase (AMPK) that promotes mitochondrial health is also known as anti-aging protein. The same enzyme plays a crucial role in life-span extension by reducing mitochondrial respiration.

Worm Research

Research on roundworms has shown that an enzyme called VRK-1 can extend their lifespan. VRK-1 does this by increasing the level of AMPK resulting in an increase in its activity, promoting longevity through phosphorylation.

This is an important finding in the research of extending human lifespan too.

Korean scientists published a paper this Wednesday in Science Advances, that showed how the lifespan of worms was extended by varying VRK-1 levels.

The Experiment

Roundworms normally have a lifespan of about two to three weeks. But the genetically engineered worms in the experiment, having elevated levels of VRK-1 lived about 23.7 days on average - they lived longer. When they inhibited the function of VRK-1 in other worms, they found that their lives were shortened.

Lab-controlled worms that lived 20.3 days on average, lived only 12.7 days as VRK-1 was inhibited. That is, the worms died sooner.

A senior author of the paper, Seung-Jae Lee, professor at the Korea Advanced Institute of Science and Technology told Inverse that the key to activating longevity was in the anti-aging protein, AMPK, while the key to activating AMPK is VRK-1. The VRK-1 enzyme is found in worms and has its cousin in human cells, that's very similar to it.

Humans?

Ageing
Representational Image Pxfuel

"Therefore, it is possible that this mechanism can be applied to promoting human longevity in the future," he added.

Similar patterns were shown in cultured human cells in the experiment, Lee said, showing that the process holds even in complex organisms.

Replicating the study in animals, like mice will show it's likeliness in humans. However, scientists still don't know how exactly the process occurs.


https://www.ibtimes.sg/one-more-key-human-longevity-found-after-worm-research-47830


List of Articles
번호 제목 글쓴이 날짜 조회 수
320 임정훈 박사 한국분자・세포생물학회 우수박사학위논문상 수상 과사무실 2004.09.09 14073
319 최길주 교수 美 광생물학회 학술지 부편집장으로 선임 과사무실 2003.09.22 14041
318 고병삼 학생 외 3명 Bioneer Award (2006) 수상 과사무실 2006.03.07 14019
317 최광욱 교수, 홍성태 박사 Nature Communications 논문 게재(2016.09) / Prof. Kwang-Wook Choi and Dr. Sung-Tae Hong published a paper in Nature Communications 생명과학과 2016.10.06 13964
316 생명과학과 출신 곽유상 박사 ... 美 대학교수 됐다 과사무실 2007.07.31 13908
315 [서울경제] 생물분야: KAIST 생물사업단 선정 과사무실 2004.12.09 13905
314 [조선일보] 생명과학과 김정회교수팀...자일리톨 추출 신기술 개발 과사무실 2007.08.29 13887
313 조병관 교수, 세계경제포럼 Young Scientist 에 선정! 과사무실 2012.09.17 13835
312 송지준 교수, J.Am.Chem.Soc. 게재 (2013.10) 과사무실 2013.10.18 13795
311 김선창 교수 송암학술상 수상 과사무실 2003.12.23 13771
310 "당뇨병 합병증 치료단백질 개발!" - 고규영교수팀 과사무실 2006.03.14 13744
309 김진우 교수, 김남석 박사 eLife지 논문 발표 (2014. 9) 과사무실 2014.09.11 13709
308 최길주 교수, PNAS(P Natl Acad Sci USA) 4월호에 논문 게재 과사무실 2009.04.23 13691
307 정유진 석사과정 학생, 조병관 교수 Nature Communications 논문 게재(2016.06) / Yujin Jeong, a Master's degree student and Prof. Byung-Kwan Cho published a paper in Nature Communications (2016.06) 생명과학과 2016.06.07 13621
306 생명과학과 김정회 교수... 대전광역시 주최 이달의 과학기술인 상 선정 과사무실 2007.10.05 13610
305 허원도 교수, Trang T. T. Nguyen박사 PNAS지에 논문 게재(2016.08) / Prof. Won Do Heo, PhD. Trang T. T. Nguyen publish an article in PNAS (2016.08) 생명과학과 2016.08.25 13605
304 "어, 해독제가 항생제로 바뀌네" - 김학성 교수팀 단백질 설계기술 개발 과사무실 2006.02.06 13604
303 [대덕넷] 생명과학과 정종경교수... 과기부 2분기 우수과학자 10인 선정 과사무실 2007.09.04 13576
302 임대식 교수, 2016년도 한국분자세포생물학회 정기학술대회 학술상 생명과학상 소개 강연 생명과학과 2016.10.10 13560
301 임대식 교수 논문 Nature Cell Biology 게재 1 과사무실 2004.01.26 13559
Board Pagination Prev 1 2 3 4 5 6 7 8 9 10 ... 20 Next
/ 20