KAIST 생명과학과동창회
  • News & Events
  • News

News

 

Scientists Identify Source of Weight Gain From Antipsychotics

New findings identify molecular mechanism behind rapid weight gain in patients treated with risperidone
12-May-2021 10:00 AM EDTby UT Southwestern Medical Center

 Newswise — DALLAS – May 12, 2021 – Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.

“If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect,” says lead author Chen Liu, Ph.D., assistant professor of internal medicine and neuroscience, and with UTSW’s O’Donnell Brain Institute and Hypothalamic Research Center.

Up to 20 percent of people who take risperidone, an atypical antipsychotic prescribed for a wide variety of neuropsychiatric conditions, add more than 7 percent to their baseline weight within a few weeks of treatment, contributing to other health problems such as high blood cholesterol and type 2 diabetes. The weight gain leads many patients to stop using the medication.

In the study, Liu and his colleagues developed a diet for mice that incorporates the drug and identified changes in gene expression and neuronal activity within the animals’ hypothalamus, a brain region long associated with appetite control. They quickly honed in on a gene called melanocortin 4 (Mc4r), which also is linked to obesity in humans. The Food and Drug Administration recently approved a drug that promotes Mc4r activity to treat some genetic forms of obesity, and Liu and his team showed that giving mice this drug along with risperidone prevented weight gain while maintaining effective treatment in models of schizophrenia – offering hope that this strategy might be effective for human patients as well.

The study was funded by grants from the National Institutes of Health (R01 DK114036, F32DK116427, K01AA024809) and the Korean National Research Foundation (2019R1A2C2005161).

Other researchers who contributed to this study include Li Li, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, and Shari G. Birnbaum, all of UTSW; Lin Jia, of UT Dallas; and Eun-Seon Yoo and Jong-Woo Sohn, of Korea Advanced Institute of Science and Technology.

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 25 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 117,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 3 million outpatient visits a year.

 

https://www.newswise.com/articles/scientists-identify-source-of-weight-gain-from-antipsychotics?ta=home

 

https://dallasinnovates.com/utsw-scientists-find-source-of-rapid-weight-gain-from-antipsychotics/

 

List of Articles
번호 제목 글쓴이 날짜 조회 수
169 생명과학과 박태관 교수, 새로운 항암유전자 전달시스템 개발 과사무실 2008.07.08 15030
168 생명과학과 신임교원 David Helfman 박사 부임 소개 (2009.8.1) 과사무실 2009.09.10 12098
167 생명과학과 신임교원 강석조 박사 소개 (2010.01.01) 과사무실 2009.12.29 16252
166 생명과학과 신임교원 오병하 박사 부임 소개 (2009.9.1) 과사무실 2009.09.10 14202
165 생명과학과 신임교원 한진희 박사 소개 (2009.10.01) 과사무실 2009.10.06 16347
164 생명과학과 신임교원 허원도 박사 부임 예정 과사무실 2007.10.16 15145
163 생명과학과 이문수 박사(이노테라피 CEO) 지혈제로 240억 '주식 갑부' file 생명과학과 2019.02.07 6645
162 생명과학과 최길주 교수, 빛 없이 싹틔우는 유전자 발견 과사무실 2008.05.30 12668
161 생명과학과 출신 곽유상 박사 ... 美 대학교수 됐다 과사무실 2007.07.31 14019
160 서경배재단 ‘올해의 신진 과학자’ 조원기 교수 선정 생명과학과 2020.09.16 4003
159 서라민 박사과정 학생. 제 18차 KHUPO 프로테오믹스 국제학술대회 수상 file 생명과학과 2018.04.30 13685
158 서성배 교수, 당뇨에 큰 영향 미치는 뇌 혈당조절 신경세포 발견 file 생명과학과 2019.10.30 4738
157 서성배 교수, 스트레스 세포(CRF 세포) 변화 초 단위 관찰 성공 file 생명과학과 2019.04.18 7277
156 서성배 교수님(김보람 연수연구원)_제20회 한국 로레알-유네스코 여성과학자상 수상 file 생명과학과 2021.09.27 1193
155 서성배 교수님(김진은 석박사통합과정)_2020 대한민국 인재상 수상 생명과학과 2021.02.25 1818
154 서성배 교수님(양대욱 박사)_세종과학펠로우십 선정 생명과학과 2021.03.18 955
153 서성배 교수님_Gut hormone triggers craving for more proteins 생명과학과 2021.05.18 665
152 서성배 교수님_동물 뇌 신경세포가 과식 억제한다 생명과학과 2021.06.16 623
151 서성배 교수님_동물의 식습관을 조절하는 원리 규명해 네이처 게재​ 생명과학과 2021.05.11 549
150 서연수 교수 생명과학상 수상 과사무실 2003.09.08 14251
Board Pagination Prev 1 ... 9 10 11 12 13 14 15 16 17 18 ... 22 Next
/ 22