KAIST 생명과학과동창회
  • News & Events
  • News

News

 

Scientists Identify Source of Weight Gain From Antipsychotics

New findings identify molecular mechanism behind rapid weight gain in patients treated with risperidone
12-May-2021 10:00 AM EDTby UT Southwestern Medical Center

 Newswise — DALLAS – May 12, 2021 – Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.

“If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect,” says lead author Chen Liu, Ph.D., assistant professor of internal medicine and neuroscience, and with UTSW’s O’Donnell Brain Institute and Hypothalamic Research Center.

Up to 20 percent of people who take risperidone, an atypical antipsychotic prescribed for a wide variety of neuropsychiatric conditions, add more than 7 percent to their baseline weight within a few weeks of treatment, contributing to other health problems such as high blood cholesterol and type 2 diabetes. The weight gain leads many patients to stop using the medication.

In the study, Liu and his colleagues developed a diet for mice that incorporates the drug and identified changes in gene expression and neuronal activity within the animals’ hypothalamus, a brain region long associated with appetite control. They quickly honed in on a gene called melanocortin 4 (Mc4r), which also is linked to obesity in humans. The Food and Drug Administration recently approved a drug that promotes Mc4r activity to treat some genetic forms of obesity, and Liu and his team showed that giving mice this drug along with risperidone prevented weight gain while maintaining effective treatment in models of schizophrenia – offering hope that this strategy might be effective for human patients as well.

The study was funded by grants from the National Institutes of Health (R01 DK114036, F32DK116427, K01AA024809) and the Korean National Research Foundation (2019R1A2C2005161).

Other researchers who contributed to this study include Li Li, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, and Shari G. Birnbaum, all of UTSW; Lin Jia, of UT Dallas; and Eun-Seon Yoo and Jong-Woo Sohn, of Korea Advanced Institute of Science and Technology.

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 25 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 117,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 3 million outpatient visits a year.

 

https://www.newswise.com/articles/scientists-identify-source-of-weight-gain-from-antipsychotics?ta=home

 

https://dallasinnovates.com/utsw-scientists-find-source-of-rapid-weight-gain-from-antipsychotics/

 

List of Articles
번호 제목 글쓴이 날짜 조회 수
168 김정현 박사과정 학생 (최길주 교수님 lab), AOCP 2015 우수 포스터상 1등 수상! / Junghyun Kim (PhD Candidate; Giltsu Choi's lab) won the Best poster award at AOCP 2015. file 생명과학과 2015.12.11 16661
167 김정진 Post-doc(김대수 교수 lab), 2011 일본뇌신경학회 Travel Award 수상! 과사무실 2011.06.17 12138
166 김재훈 교수, 강현아, 권부기 학생 '청암과학펠로' 선정 과사무실 2011.11.04 18266
165 김재훈 교수, Molecular Cell 게재 (2013.3) 과사무실 2013.04.01 12576
164 김재현 박사과정 학생, 이승희 교수 J.Neurosci. 게재 (2016.05) / Jae-Hyun Kim and Prof. Seung-Hee Lee published article at J. Neurosci. (2016.05) 생명과학과 2016.05.18 17530
163 김재섭 교수 논문 Nature Genetics 게재 과사무실 2005.01.31 13283
162 김은준교수 실험실, Nature Neuroscience 에 논문 게재(2015.01) / Professor Eun Joon Kim’s Lab Publishes in Nature Neuroscience 과사무실 2015.01.27 18853
161 김은준 서연수 교수 우수교원 포상 과사무실 2004.02.13 12992
160 김은준 교수팀, 시냅스 가소성 조절 단백질 발견 과사무실 2009.09.14 11237
159 김은준 교수님_시냅스 뇌질환 연구 김은준 IBS단장 “치료약 없는 자폐 연구 도전” 생명과학과 2021.08.23 412
158 김은준 교수, 제 26회 인촌상 수상! 과사무실 2012.08.30 11607
157 김은준 교수, 올해의 KAIST인상 수상 file 과사무실 2015.01.06 15831
156 김은준 교수, 뇌 속 시냅스 생성 단백질 발견 과사무실 2009.04.06 11233
155 김은준 교수, 기초과학연구원(IBS) 연구단장 10명에 선정! 과사무실 2012.05.09 14958
154 김은준 교수, KAIST 지정 석좌교수로 임명 과사무실 2011.05.20 11280
153 김은준 교수, '아산의학상' 기초의학 부문 수상자로 선정 file 생명과학과 2018.01.16 10891
152 김은준 교수 포스코청암상 수상 과사무실 2013.02.05 11538
151 김은준 교수 창의과제 신규 선정 과사무실 2003.09.08 14500
150 김은준 교수 연구팀, 자폐증 치료 가능성 열어 과사무실 2012.06.15 14079
149 김세윤교수님_보톡스처럼 신경 활성 억제하는 뇌 속 생체물질 찾았다 file 생명과학과 2020.03.26 3537
Board Pagination Prev 1 ... 7 8 9 10 11 12 13 14 15 16 ... 20 Next
/ 20