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Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequences.


Abstract

Genome stability is essential for all organisms. Translationally controlled tumour protein (TCTP) is a conserved protein associated with cancers. TCTP is involved in multiple intracellular functions, but its role in transcription and genome stability is poorly understood. Here, we demonstrate new functions of Drosophila TCTP (Tctp) in transcription and the stability of repeated sequences (rDNA and pericentromeric heterochromatin). Tctp binds Brahma (Brm) chromatin remodeler to negatively modulate its activity. Tctp mutants show abnormally high levels of transcription in a large set of genes and transposons. These defects are ameliorated by brm mutations. Furthermore, Tctp promotes the stability of repeated sequences by opposing the Brm function. Additional regulation of pericentromeric heterochromatin by Tctp is mediated by su(var)3-9 transcriptional regulation. Altogether, Tctp regulates transcription and the stability of repeated sequences by antagonizing excess Brm activity. This study provides insights into broader nuclear TCTP functions for the maintenance of genome stability.


List of Articles
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197 전상용 교수, 94회 일본화학회 정기학회 'Distinguished Lectureship Award' 수상 과사무실 2014.04.02 12873
196 김학성 교수, Nature Communications 게재 (2014. 4) 과사무실 2014.04.24 13166
195 허원도 교수, Nature Methods 게재 (2014. 5) 과사무실 2014.05.08 20137
194 김대진 학생 (전상용 교수님 Lab) 생화학분자생물학회(KSBMB) Sanofi 신약 연구상 수상! 과사무실 2014.05.29 14036
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192 김학성 교수, Molecular Therapy에 표지논문 게재 (2014.7) 과사무실 2014.07.09 11753
191 허원도 교수, Chemistry & Biology지 표지논문 게재 과사무실 2014.07.22 15030
190 최길주 교수, 정진길 박사 Nature Communications지 논문 게재 (2014. 8) 과사무실 2014.09.11 13280
189 김진우 교수, 김남석 박사 eLife지 논문 발표 (2014. 9) 과사무실 2014.09.11 13661
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185 김은준교수 실험실, Nature Neuroscience 에 논문 게재(2015.01) / Professor Eun Joon Kim’s Lab Publishes in Nature Neuroscience 과사무실 2015.01.27 18908
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