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Antagonistic roles of Drosophila Tctp and Brahma in chromatin remodelling and stabilizing repeated sequences.


Genome stability is essential for all organisms. Translationally controlled tumour protein (TCTP) is a conserved protein associated with cancers. TCTP is involved in multiple intracellular functions, but its role in transcription and genome stability is poorly understood. Here, we demonstrate new functions of Drosophila TCTP (Tctp) in transcription and the stability of repeated sequences (rDNA and pericentromeric heterochromatin). Tctp binds Brahma (Brm) chromatin remodeler to negatively modulate its activity. Tctp mutants show abnormally high levels of transcription in a large set of genes and transposons. These defects are ameliorated by brm mutations. Furthermore, Tctp promotes the stability of repeated sequences by opposing the Brm function. Additional regulation of pericentromeric heterochromatin by Tctp is mediated by su(var)3-9 transcriptional regulation. Altogether, Tctp regulates transcription and the stability of repeated sequences by antagonizing excess Brm activity. This study provides insights into broader nuclear TCTP functions for the maintenance of genome stability.

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198 전상용 교수, Cancer Research게제(2014.2) 과사무실 2014.03.12 12954
197 전상용 교수, 94회 일본화학회 정기학회 'Distinguished Lectureship Award' 수상 과사무실 2014.04.02 12873
196 김학성 교수, Nature Communications 게재 (2014. 4) 과사무실 2014.04.24 13166
195 허원도 교수, Nature Methods 게재 (2014. 5) 과사무실 2014.05.08 20137
194 김대진 학생 (전상용 교수님 Lab) 생화학분자생물학회(KSBMB) Sanofi 신약 연구상 수상! 과사무실 2014.05.29 14036
193 허원도 교수, Nature Communications지 논문 게재 (2014. 6) 과사무실 2014.06.05 14125
192 김학성 교수, Molecular Therapy에 표지논문 게재 (2014.7) 과사무실 2014.07.09 11753
191 허원도 교수, Chemistry & Biology지 표지논문 게재 과사무실 2014.07.22 15030
190 최길주 교수, 정진길 박사 Nature Communications지 논문 게재 (2014. 8) 과사무실 2014.09.11 13280
189 김진우 교수, 김남석 박사 eLife지 논문 발표 (2014. 9) 과사무실 2014.09.11 13661
188 김학성 교수, 류이슬 박사 Angewandte Chemie 논문 발표(2014.11) 과사무실 2014.11.27 12669
187 김은준 교수, 올해의 KAIST인상 수상 file 과사무실 2015.01.06 15852
186 최광욱 교수, 2014 국내 바이오분야 연구성과 및 뉴스 Top5 선정 / Prof. Kwang-Wook Choi was selected as Top 5 news of 2014 in domestic bio research field 과사무실 2015.01.15 13199
185 김은준교수 실험실, Nature Neuroscience 에 논문 게재(2015.01) / Professor Eun Joon Kim’s Lab Publishes in Nature Neuroscience 과사무실 2015.01.27 18908
184 임대식 교수, 김민철 박사 Cell Reports 에 논문 게재(2015.03) / Professor Dae-Sik Lim and Min Cheol Kim, Ph.D Publish in Cell Reports (2015.03) 과사무실 2015.04.06 14307
183 전상용 교수, Theranostics 저널 최다 피인용 논문상 수상 / Professor Sangyong Jon receives The Most Cited Paper Award by the “Theranostics” Journal 과사무실 2015.04.21 12309
182 송지준 교수, 김은지 박사 Molecular Cell에 논문 게재(2015) / Prof. Ji-Joon Song and PhD. Eun-Ji Kim published a paper at Molecular Cell (2015) 과사무실 2015.07.29 14220
181 최길주 교수, 이나영 박사 The Plant Cell 게재(2015.08) / Prof. Giltsy Choi and PhD. Nayoung Lee published a paper at The Plant Cell 과사무실 2015.08.19 15231
180 김선창 교수 실험실(양경석 박사과정) ACS Catalysis 논문게재 (2015.07) / Kyung Seok Yang (prof. Sun Chang KIm's Lab) published a paper in ACS Catalysis 과사무실 2015.08.20 15686
179 김학성 교수, 이중재 박사 Angewandte Chemie에 논문 게재 (2015) / Prof. Hak-Sung Kin and PhD. Joong-Jae Lee published a paper at Angewandte Chemie (2015) 생명과학과 2015.08.31 15068
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