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1. 수상자/강연자: 정재웅 박사
(美 남가주대 KECK 의대 교수, KAIST 생명과학과 겸임교수)

2. 일시: 2012. 5. 2 (수) 오후 4시

3. 장소: KAIST KI빌딩(E4) 1층 퓨전홀

4. 주최: KAIST 생명과학과, KI 바이오융합연구소, ISBC 글로벌프론티어 연구단, KAIST-USC 글로벌연구소, 호암재단

* 강연 제목 및 초록

Host-Pathogen Standoff: Roles of Pattern Recognizing Receptors and Intracellular Restriction Factors in Antiviral Immune Response

Understanding the host-viral interaction is an essential step in developing safe and effective anti-microbials against viruses. Since virus is most vulnerable at the early stage of lifecycle, this stage should therefore offer the best opportunity for therapeutic interventions. The early detection of invading viruses by the host depends on a limited number of Pattern Recognizing Receptors (PRRs) that serve as the primary intracellular sensors for viral specific genetic patterns and activate signal transduction cascades, thereby triggering interferon (IFN)-mediated antiviral defense mechanisms. Key virus-detecting PRRs include the nucleic acid-recognizing Toll-like receptors and the cytosolic RNA receptors RIG-I and MDA-5. Specifically, RIG-I has emerged as a key receptor in sensing viruses, including the influenza virus and hepatitis virus C (HCV), whereas MDA5 responds to the infection of picornaviruses and noroviruses. Upon viral infection, RIG-I undergoes the multiple step processes of ATP-dependent structural and functional activations to elicit IFN-mediated antiviral signal transduction. In addition, members of the tripartite motif (TRIM) proteins and the Linear Ubiquitination Assembly Complex (LUBAC) proteins also play major roles in the IFN-mediated inhibition of the lifecycles of viruses.

Following the PRR-mediated viral sensing, hosts subsequently elicit intracellular

List of Articles
번호 제목 글쓴이 날짜 조회 수
공지 [2022 대성해강미생물포럼] 여러분을 초대합니다.(참가등록: ~ 9/16) 생명과학과 2022.09.07 55
공지 제29회 삼성휴먼테크논문대상 안내 (초록접수 : 9/1(목)~10/5(수) 14시) file 생명과학과 2022.09.01 40
공지 2022 Agarwal Award 시상식 개최 안내 file 생명과학과 2022.08.29 60
공지 생명과학과 2021년 학과설명회 동영상 생명과학과 2021.11.25 940
공지 Revised (2021-03-18) :생명과학과 박사학위논문계획서 및 자격시험 가이드 라인 ( Ph.D. Thesis Proposal and Qualifying Examination Guidlines) file 생명과학과 2021.05.13 1341
공지 대학원과정 재학년한 연장신청 안내 Application for Extension of Prescribed Time Limit for Graduate Students file 생명과학과 2020.06.03 20914
공지 박사 프로포잘 및 자격시험 심사 안내 (Ph.D Thesis Proposal and Qualifying Examination) file 생명과학과 2020.05.13 21413
공지 코로나19 확산에 따른 학생 대면업무 조치계획 안내 Face-to-Face Situation Action Plan Notice For prevention of Spread of COVID-19 생명과학과 2020.03.03 23762
공지 Ph.D. Thesis Proposal 실시 안내 / 박사과정 입학 후 또는 박사과정 인정시점 1년 이내 완료하여야 함 file 생명과학과 2017.06.28 55279
공지 생명과학과 이수요건 안내 (학사과정 / 대학원과정) file 생명과학과 2017.02.15 61195
249 SK(주) 홀딩스 18년 대졸 인턴 채용 공고 file 생명과학과 2018.04.04 7519
248 Revised Ph.D. Thesis Proposal and Qualifying Examination Guidlines file 생명과학과 2020.11.18 11188
247 Research Associate in the King's College London 생명과학과 2019.01.29 7813
246 Research Associate (DRI) in the Department of Basic and Clinical Neuroscience file 생명과학과 2018.06.14 7290
245 Postdoctoral Positions Laboratory of Jae Ung Jung, University of Southern California file 생명과학과 2019.10.15 4301
244 Postdoctoral Positions available - Prof. David Wallach's Laboratory 생명과학과 2018.04.18 5805
243 Postdoctoral Positions available - Baxter Laboratory file 생명과학과 2017.05.10 8525
242 Postdoctoral position in Synapse Biology(The Lee Lab at the Medical College of Wisconsin) file 생명과학과 2019.12.11 3320
241 Postdoctoral Position in Cancer Bology at Cold Spring Harbor Laboratory(CSHL) file 생명과학과 2016.07.12 8713
240 Postdoctoral Fellowship Position in Neurobiology of Autism at the University of Texas Health file 생명과학과 2019.01.29 5407
239 Post-Doctoral position on mycobacterial pathogenicity at IPBS - Toulouse(France) file 생명과학과 2017.01.10 8966
238 Post-Doc 채용 공고 - Washington University School of Medicine in St. Louis file 생명과학과 2019.10.07 3709
237 Post-Doc 채용 공고 - USC (Jae Jung's Laboratory) file 생명과학과 2020.05.15 2206
236 Post-Doc 채용 공고 - University of Michigan Medical School file 생명과학과 2020.04.02 2044
235 Post-Doc 채용 공고 - UC Irvine, Jang Lab (Nutrient Metabolism) 생명과학과 2020.03.30 2516
234 Post-Doc 채용 공고 - UC Irvine, Gina Lee Lab (RNA Metabolism) 생명과학과 2020.03.29 2663
233 Post-Doc 채용 공고 - Oregon Health & Science University 생명과학과 2018.12.18 5354
232 Positions available in Byun Laboratory Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City 생명과학과 2016.12.14 10627
231 Position: Molecular Postdoctoral Fellow position is available at the Massachusetts General Hospital / Harvard Medical School. file 생명과학과 2016.12.23 8839
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