KAIST 생명과학과동창회
  • News & Events
  • News

News

 

Scientists Identify Source of Weight Gain From Antipsychotics

New findings identify molecular mechanism behind rapid weight gain in patients treated with risperidone
12-May-2021 10:00 AM EDTby UT Southwestern Medical Center

 Newswise — DALLAS – May 12, 2021 – Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.

“If this effect can be shown in clinical trials, it could give us a way to effectively treat patients for their neuropsychiatric conditions without this serious side effect,” says lead author Chen Liu, Ph.D., assistant professor of internal medicine and neuroscience, and with UTSW’s O’Donnell Brain Institute and Hypothalamic Research Center.

Up to 20 percent of people who take risperidone, an atypical antipsychotic prescribed for a wide variety of neuropsychiatric conditions, add more than 7 percent to their baseline weight within a few weeks of treatment, contributing to other health problems such as high blood cholesterol and type 2 diabetes. The weight gain leads many patients to stop using the medication.

In the study, Liu and his colleagues developed a diet for mice that incorporates the drug and identified changes in gene expression and neuronal activity within the animals’ hypothalamus, a brain region long associated with appetite control. They quickly honed in on a gene called melanocortin 4 (Mc4r), which also is linked to obesity in humans. The Food and Drug Administration recently approved a drug that promotes Mc4r activity to treat some genetic forms of obesity, and Liu and his team showed that giving mice this drug along with risperidone prevented weight gain while maintaining effective treatment in models of schizophrenia – offering hope that this strategy might be effective for human patients as well.

The study was funded by grants from the National Institutes of Health (R01 DK114036, F32DK116427, K01AA024809) and the Korean National Research Foundation (2019R1A2C2005161).

Other researchers who contributed to this study include Li Li, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, and Shari G. Birnbaum, all of UTSW; Lin Jia, of UT Dallas; and Eun-Seon Yoo and Jong-Woo Sohn, of Korea Advanced Institute of Science and Technology.

About UT Southwestern Medical Center

UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes, and includes 25 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 117,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 3 million outpatient visits a year.

 

https://www.newswise.com/articles/scientists-identify-source-of-weight-gain-from-antipsychotics?ta=home

 

https://dallasinnovates.com/utsw-scientists-find-source-of-rapid-weight-gain-from-antipsychotics/

 

List of Articles
번호 제목 글쓴이 날짜 조회 수
260 과사무실 최은주 사무원 - 2005년도 4/4분기 "이 달의 직원상" 수상 과사무실 2005.11.01 10590
259 박태관 교수 나노연구혁신 대상(과학기술부 장관상) 수상 과사무실 2006.09.04 10686
258 강창원 교수, "디아이 학술상" 수상! 과사무실 2012.05.22 10707
257 임대식 교수 외 3명 개교 34주년 기념 우수교원 포상 과사무실 2005.02.15 10793
256 고창민 박사과정 학생, 최광욱 교수 Oncogene 게재(2016.04) / Chang Min Ko, a Ph.D candidate and Prof. Kwang-Wook Choi published a paper in Oncogene (2016.04) 생명과학과 2016.04.15 10799
255 [매일경제] 김학성 오은규 연구팀 나노입자 특성 이용해 단백질 상호작용 분석 과사무실 2005.03.21 10820
254 [대덕넷] 제넥셀, 日 신약개발업체서 외자유치 과사무실 2005.03.31 10836
253 2015년 KAIST 대표 R&D 연구성과 10선 선정 / Announcement of KAIST's Top 10 Research Accomplishments of 2015 생명과학과 2016.03.07 10837
252 [한겨레] 생체시계 시간 맞추는 유전자 국내 연구팀이 첫 발견-김재섭 교수팀 과사무실 2005.10.20 10859
251 최길주 교수, PNAS 에 논문 게재! (2012. 1 online) 과사무실 2012.01.12 10866
250 2011년 개교 40주년 기념 우수교원 포상 과사무실 2011.02.11 10879
249 최유라 학생 21세기 이끌 우수인재상 수상 과사무실 2005.01.27 11081
248 1단계 BK21사업 성과보고대회 - 우수사업단 선정 및 부총리 표창 과사무실 2005.12.19 11134
247 김학성 교수, 2010년 한국바이오칩학회 학술대상 수상! 과사무실 2010.11.01 11140
246 배기현 학생 창의활동상 수상 과사무실 2005.02.17 11146
245 한진희 교수, 선천적 공포 반응에 대한 신경회로 첫 규명 file 생명과학과 2018.08.08 11162
244 박태관 교수, 미국생체재료학회 클렘슨상 수상! 과사무실 2009.04.02 11165
243 생명과학과 김정회 교수... 한국생물공학회 학술상 수상 과사무실 2007.10.24 11179
242 2009년 개교 38주년 기념 우수교원 포상 과사무실 2009.02.17 11218
241 [동아일보] 노화억제 신약후보물질 개발…김태국 교수팀 과사무실 2006.06.12 11235
Board Pagination Prev 1 ... 3 4 5 6 7 8 9 10 11 12 ... 20 Next
/ 20