KAIST 생명과학과동창회
  • News & Events
  • News

News

One More Key to Human Longevity Found After Worm Research

Korean scientists zero in on an enzyme called VRK-1 in roundworm research that can extend their lifespan


It is known that the mitochondria is called the powerhouse of the cell, without which there will be no energy production in the cell, thereby the body too! Along with this mitochondria has its role in other important functions, one crucial role being in aging.

Research has shown that age-related diseases are linked to mitochondrial functioning. Further, it is known that "mild inhibition of mitochondrial respiration" promotes longevity in many species, which means to mildly slow down mitochondria's energy-making process. Thus, the life-span extension compensates for the reduced mitochondrial respiration.

VRK-1 is a nuclear protein that increases worm life span
VRK-1 is a nuclear protein that increases worm life span From the Research Paper

An enzyme called AMP-activated protein kinase (AMPK) that promotes mitochondrial health is also known as anti-aging protein. The same enzyme plays a crucial role in life-span extension by reducing mitochondrial respiration.

Worm Research

Research on roundworms has shown that an enzyme called VRK-1 can extend their lifespan. VRK-1 does this by increasing the level of AMPK resulting in an increase in its activity, promoting longevity through phosphorylation.

This is an important finding in the research of extending human lifespan too.

Korean scientists published a paper this Wednesday in Science Advances, that showed how the lifespan of worms was extended by varying VRK-1 levels.

The Experiment

Roundworms normally have a lifespan of about two to three weeks. But the genetically engineered worms in the experiment, having elevated levels of VRK-1 lived about 23.7 days on average - they lived longer. When they inhibited the function of VRK-1 in other worms, they found that their lives were shortened.

Lab-controlled worms that lived 20.3 days on average, lived only 12.7 days as VRK-1 was inhibited. That is, the worms died sooner.

A senior author of the paper, Seung-Jae Lee, professor at the Korea Advanced Institute of Science and Technology told Inverse that the key to activating longevity was in the anti-aging protein, AMPK, while the key to activating AMPK is VRK-1. The VRK-1 enzyme is found in worms and has its cousin in human cells, that's very similar to it.

Humans?

Ageing
Representational Image Pxfuel

"Therefore, it is possible that this mechanism can be applied to promoting human longevity in the future," he added.

Similar patterns were shown in cultured human cells in the experiment, Lee said, showing that the process holds even in complex organisms.

Replicating the study in animals, like mice will show it's likeliness in humans. However, scientists still don't know how exactly the process occurs.


https://www.ibtimes.sg/one-more-key-human-longevity-found-after-worm-research-47830


List of Articles
번호 제목 글쓴이 날짜 조회 수
136 김경란, 김민진, 김태형 (강창원 교수 lab) 2010’캠퍼스 특허전략 유니버시아드 대회 장려상 수상! 과사무실 2010.12.13 14876
135 권석규 학생(김은준 교수 lab), 2009' 석림학술장학재단 장학생으로 선정! 과사무실 2009.12.22 12737
134 과사무실 최은주 사무원 - 2005년도 4/4분기 "이 달의 직원상" 수상 과사무실 2005.11.01 10538
133 과사무실 김미희님 - 2007년도 4/4분기 "이 달의 직원상" 수상 과사무실 2007.11.16 12145
132 고창민 박사과정 학생, 최광욱 교수 Oncogene 게재(2016.04) / Chang Min Ko, a Ph.D candidate and Prof. Kwang-Wook Choi published a paper in Oncogene (2016.04) 생명과학과 2016.04.15 10727
131 고병삼 학생 외 3명 Bioneer Award (2006) 수상 과사무실 2006.03.07 13965
130 고규영 교수님 Circulation Research 논문 COVER게재 과사무실 2007.03.21 13259
129 고규영 교수 국가지정연구실사업 신규과제 선정 과사무실 2004.08.23 12168
128 개교 45주년 기념 우수교원 수상 / Announcement of the 2016 Faculty Award Winners in Commemoration of the 45th Anniversary of Founding 생명과학과 2016.03.07 9590
127 개교 36주년 기념 우수교원 포상 과사무실 2007.02.15 9852
126 개교 35주년 기념 우수교원 포상 - 김태국 교수(학술상), 김학성 교수(국제협력상) 과사무실 2006.02.15 11829
125 강창원, 김은준 교수팀, ADHD 유전자 찾았다 과사무실 2011.04.18 14362
124 강창원 교수님 생물학 교과서 다시 쓴다… RNA 합성 재생단계 국내 학계서 최초 규명 file 생명과학과 2020.01.29 4766
123 강창원 교수, 한빛대상 수상! 과사무실 2011.09.28 12962
122 강창원 교수, KT 석좌교수 임용 과사무실 2014.02.26 11967
121 강창원 교수, 2016년 제2회 바이오유공자 장관표창 수상 생명과학과 2016.11.10 11955
120 강창원 교수, 2010년 기초연구 우수성과 선정! 과사무실 2010.11.08 11543
119 강창원 교수, 2010년 국가연구개발 우수성과 100선에 선정 과사무실 2010.12.13 11253
118 강창원 교수, (통합)생화학분자생물학회 2010년도 회장 선임 과사무실 2009.11.05 12299
117 강창원 교수, "디아이 학술상" 수상! 과사무실 2012.05.22 10627
Board Pagination Prev 1 ... 9 10 11 12 13 14 15 16 17 18 ... 20 Next
/ 20