Park WY, Hong BJ, Lee J, Choi C, Kim MY. H3K27 Demethylase JMJD3 Employs the NF-kappaB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis. Cancer research 2016;76(1):161-70.

 

히스톤 탈메틸화 효소인 JMJD3의 NF-kB 및 BMP pathway를 통한 흑색종 발생 및 전이 조절 기작 규명

 

히스톤 H3K27 디메틸화 효소인 JMJD3가 NF-kappaB 및 BMP pathway와 함께 타겟 유전자들을 조절하여 줄기세포화 및 암세포미세환경을 변화시킴으로써 흑색종 발생 및 전이에 중요한 역할을 한다는 것을 밝힌 논문이다.

 

Woo-Yong Park, a Ph.D candidate in Prof. Mi-Young Kim’s lab published a paper in Cancer Research (2016. 1).

 

Park WY, Hong BJ, Lee J, Choi C, Kim MY. H3K27 Demethylase JMJD3 Employs the NF-kappaB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis. Cancer research 2016;76(1):161-70.

 

H3K27 Demethylase JMJD3 Employs the NF-kB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis

 

Woo-Yong Park, a Ph.D candidate in Prof. Mi-Young Kim’s lab revealed the mechanism by which JMJD3, NF-kB and BMP signaling pathways coordinately regulate melanoma progression and metastasis by modulating stem cell-like properties of melanoma cells and the tumor microenvironment.