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허원도, 김대수, 한용만 교수 공동연구팀은 청색 빛에 반응하는 식물의 광수용체 단백질 (Cryptochrome 2)과 인간의 칼슘 채널 활성화 단백질 (STIM1)을 융합하여 빛에 의해 칼슘이온을 세포 내로 유입시킬 수 있는 기술을 개발하였다.
본 기술을 암세포, 인간배아줄기세포, 제브라피쉬 등에 적용하여 폭넓은 응용 가능성을 보여주는 한편 쥐의 뇌 부위 중 해마 (hippocampus)에 적용시켜 쥐의 단기 기억력을 증가시킴으로써 향후 세포 내 칼슘 조절에 이상이 생겨 발생하는 각종 질환의 치료법 연구에 기여할 수 있을 것이라 기대한다.
 
"Optogenetic control of endogenous Ca2+ channels in vivo" 
 
Taeyoon Kyung*, Sangkyu Lee*, Jung Eun Kim, Taesup Cho, Hyerim Park, Yun-Mi Jeong, Dongkyu Kim, Anna Shin, Sungsoo Kim, Jinhee Baek, Jihoon Kim, Na Yeon Kim, Doyeon Woo, Sujin Chae, Cheol-Hee Kim, Hee-sup Shin, Yong-Mahn Han, Daesoo Kim, and Won Do Heo
Nat. Biotechnol. 33, 1092-1096 (2015).

논문관련 뉴스 기사 링크

Nature Biotechnology지 10월호 표지로 선정
 
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